The Most Powerful Longevity Compound in the World is Being Discovered…

Learn More Now

full disclaimer a lot of the things that we're going to be talking about today are things that have been studied in rodent models that have been studied in vitro and cultured cells but this is interesting stuff and when you're looking at the world of biohacking you have to be able to sort of look ahead a little bit if we always wait for evidence to come out in humans we'd obviously be late to the game so although we don't take this stuff 100 to the bank and take it as literal fact we can still look at these rodent model studies and extrapolate very interesting potential mechanisms to see why this might be something interesting so today we're talking about spermidine spermidine is a specific kind of what is called a polyamine okay so a polyamines are groups of aminos okay they're very specific groups of aminos that may have free radical neutralizing capabilities they may have anti-inflammatory capabilities they may have gene expression capabilities they do very interesting things and spermidine has been really under the microscope no pun intended a lot recently because we've been starting to see it in the longevity communities as something that's a very powerful antioxidant so let's break down how it might work within the body now before you think that this is something that's just randomly created in a lab sermonine is something that you can still get extracted from like grapefruit from teas from broccoli you're just not getting it in a very concentrated form so spermuding as far as a supplement is concerned is more of a synthetic form of it and you can obviously get a lot higher concentrations of it but I want to focus mainly on the neuroprotective side okay so sperminine as a neuroprotectant is where the bulk of the research really lands and I want to talk about an initial study that looked at it in mice and how it really did offer some interesting neuroprotective effects so the study was published in the journal bio gerontology and it took a look at aging induced rats so these were rats that they artificially made them get older essentially right and what they did is they gave them 10 milligrams of spermidine per kilogram of body weight now that's a hefty dose but the results were pretty interesting they found that there was a decrease in pro-oxidants within the brain so these are things that would typically cause oxidative stress with a simultaneous increase in antioxidants within the brain okay so something is happening at a level that is up regulating sort of our endogenous production of antioxidants and down regulating decreasing oxidative stressors within the brain now specifically they saw an increase in something that's called atg3 now atgs are autophagy related proteins so they're related to sort of the cellular recycling now there's different categories of these proteins and it gets very complex very quick so in a very colloquial sense like what they do is they basically help cellular cleanup work a little bit more efficiently what's interesting is they also saw an increase in ulk one which is associated with this as well in a decrease in interleukin-6 so a decrease in neuroinflammation but they saw this mainly in the Aging mice not in the other mice which implies that there could be somewhat of a selective ability for spermidine to affect an aging brain in a positive way which is very very interesting obviously we need more research to understand this so then we kind of lead into the next category of it being a neuroprotectant which is the neural inflammation side as a matter of fact there was a study literally published in the journal neuroinflammation that took a look at what is called the beta amyloid pathway now you've probably heard of beta amyloid plaque before because it's talked about a lot in the neurodegenerative disease communities like it's a Alzheimer's things like that and over the last couple of years it's gotten a little bit more scrutiny because we're starting to understand that maybe Alzheimer's isn't only associated with beta amyloid plaque that being said these different beta amyloid proteins these ab40s ab42 things like that these are still problematic because they can still trigger inflammation so what this research set out to do was see if spermining could play a role in beta amyloid plaque sort of breaking down so they took a look at mice that were essentially they induced neurodegeneration to the point where they were had Alzheimer's okay so they had took Alzheimer's mice compared to what are called wild type mice that were healthy okay and they gave them dissolved spermidine in their water so they were sipping on it continuously and they looked at these mice when they were 30 days old 120 days old and 290 days old so what's interesting is that at 120 days and 290 days mice ended up seeing a reduction of what is called ab40 specific amyloid a beta amyloid okay now this ended up being reduced 40 percent now what's really interesting is that a different type of beta amyloid that was ab42 this decreased 49 in 290 day mice in case you haven't fallen asleep and you're still watching this video with all this what this means is that somehow spermidine is having an effect at reducing these beta amyloids that can lead to what is called beta amyloid plaque you've probably heard of beta amyloid plaque before because it's talked about all the time but people oftentimes that are talking about it don't really know what's going on so beta amyloid plaque leads to these neurofibrillary Tangles okay so these Tangles that occur within our brain and these Tangles are ultimately leading to increased levels of inflammation this is where things get kind of confusing with Alzheimer's because we don't always know what is causing the inflammation is it the disease itself is it the tangles the bottom line is that it seems to break down some of these tingles so there's less inflammation but we can't say that for certainty in a human model we see it in rodents but I'm very careful not to say that it's going to magically do this in humans now another way that spermining could be affecting the brain is you have an influx of calcium in the neuron so when this happens in an aging brain it can cause the neurons to die and for a multitude of potential reasons spermining might be kind of reducing the calcium influx into the neurons so there's a couple proposed mechanisms but again we still need to flush it out with more research now it's worth noting that luteolin has very powerful effects here as well so if you're looking at potentially experimenting with this stuff spermidine and ludolin are both very powerful in the research when it comes down to the in vitra stuff and the rodent model stuff I popped a link down below for a company called Verso that has a product called clean being which has spermidine has luteal and it has what is called the hydroqueercetin so kind of a triple punch effect when you're looking at these potential things the whole idea behind Verso clean being is to help with the cleanup processes within the body so we've got autophagy which is sort of the cellular recycling that's occurring we've got apoptosis which is like the pre-programmed cellular death we of course have the inflammatory Pathways there so the common nation of those three might work very very very well there now again this is for people that are interested in kind of experimenting with the stuff and trying it out so I pop the link down below that'll save you 15 off through Verso if you do want to check them out again the product is called clean being so it's a mix of spermidine luteolin and hydroquiristin which I've talked about in other videos just a more bioavailable form of quercetin which may be playing a really powerful role as a potential anti-inflammatory so again that link is down below check them out so they're 15 off right below this video in the top line of the description now let's jump over to the longevity piece for a second okay there was a study published in the journal Nature medicine that was taking a look at spermidine and its effect on potential longevity and again we get into rodent model studies but still very interesting so with this study they gave mice various polyamines in their water and some just get straight water the mice ended up sipping on spermining for their entire life ended up living longer now I'm not suggesting that you take spermidine for the rest of your life right this is a rodent model study and it's just it paints a picture when they have a continuous sort of flow of it there's interesting things happening they also confirmed this by checking the bioavailability of spermidine in the mice themselves so if they've been sipping on a various polyamine or spermidine for their entire life and then they check the actual bioavailable levels in the mice themselves they can cross-reference to say okay yes there are higher amounts of spermidine in this mouse the potential reason or at least speculated reason is autophagy okay again they see increases in these autophagy related proteins in this case atg7 now what this means from an autophagy perspective remember autophagy is All About Cellular recycling so taking just components of cells or organelles that are not really being used anymore and recycling them either for themselves or to ultimately be excreted right now if you have more autophagy related proteins like atg7 atg3 it means that you can form what is called an autophagosome an autophagosome is what engulfs the pathogen or what engulfs the bad material without the autophagosome there's nothing to actually like it's like a net nothing else to engulf it so in mice when you see these atg3 atg7 increase it's a very positive buy sign now the way that they've sort of confirmed this was with a study published in nature cell biology now this particular study was done with flies and some particular human immune cells so it's a little bit far-fetched but it is what it is when it comes down to looking at this data so we saw increases in atg7 but also increases in what is called becklin one both associated with autophagy especially when you look at human immune cells it's very interesting because what we don't realize is that autophagy plays a role in engulfing pathogenic material too so autophagy in the immune system do actually work more hand in hand than they're given credit for in the mainstream so with this sperminine and these other polyamines and things like ludiolin that are just powerful free radical scavengers or at least things that up regulate free radical Scavenging within our body are playing a much bigger role than what we see on the surface it's not like taking in vitamin C that's neutralizing bad things there's something deeper going on that's actually potentially helping autophagy and helping these other processes allow us sort of endogenously to be better at staving off these free radicals to live a better healthier life so again it's all research but in the world of biohacking it's what it's all about I'll see you tomorrow